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An external pulse generator for neuromodulation
Flídr, Lukáš ; Čech, Petr (referee) ; Chmelař, Milan (advisor)
The main objective of this work is to explain and familiarize with neuromodulation, its use and possibilities of its application in current medicine. It will also focus on the basic configuration and the block concept of an external generator and the time courses of the generator are described. In the first phase the base of neuromodulation is explained, then the main application, the implementation of this technology and the possibility of its application in modern medicine. Further to the work we will find an overview of equipment used for neuromodulation. The other part is focused on a design of an external generator using a MOTOROLA Nitron HC08 series microcontroller, its configuration and finally description of the time courses (impulses) from the device, that are used for neuromodulation.
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External pulse generator for neuromodulation
Flídr, Lukáš ; Říčný, Václav (referee) ; Chmelař, Milan (advisor)
This thesis deals with the treatment of chronic pain by using neuromodulation, where a external generator is used in a trial period. In the first section the principle of pain management is described and then the main nature of neuromodulation. The possibilities of chronic pain suppression are described, where we are mainly dealing with neurostimulation (stimulation with electric current). For better understanding, examples of neurostimulation usage are shown, where and in what problems it is used. Because this work deals with an external generator for a trial period (a trial system), the possibilities of testing electric impulses are described, which are then used in a implantable generator IPG. The requirements for such a external generator are also described, which are important for the design of such a device. The design of the device is firstly modeled by a block scheme, where function of the separate blocks is described and afterwards, the entire design of the external generator for neuromodulation is given. The test sample of the external generator is manufactured and tested.
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Influence of binaural beats on ideomotoric coordination
Pavlovič, Ondřej ; Pánek, David (advisor) ; Pavlů, Dagmar (referee)
Name: The effects of binaural beats on sleep quality: a systematic review Aims of the study: The main objective of this study is to present the possibilities of influencing stress and sleep, to determine the effect of binaural beats (BB) stimulation on sleep quality and parameters, and to determine the specifics of effective BB therapy based on the available data. Materials and methods: This systematic review includes scientific articles and clinical studies published in relevant and/or peer-reviewed journals and conference proceedings. Three electronic databases (Web of Science, Scopus, PubMed) were searched for all available sources published from 2000 to January 2023 in English language. The search was conducted using relevant keywords and their combinations. The screening and subsequent process of elimination was based on set of eligibility and inclusion criteria. Results: Total of fourteen studies met the eligibility criteria. BB stimulation increased subjectively perceived sleep quality and reduced mental tension. Objectively, it reduces time of falling asleep, accelerates the onset of deeper sleep stages (N2 and N3) and increases their duration, as well as the total sleep time. The parameters optimal for effective BB stimulation can be laid out as follows: BB in the frequency range of 2 to 4...
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Treatment of eating disorders through neurostimulation methods
Baumann, Silvie ; Papežová, Hana (advisor) ; Ustohal, Libor (referee) ; Stárková, Libuše (referee)
Background: Eating disorders are psychiatric illnesses whose treatment is difficult and usually the classic procedures fail. Recently, the number of researches in neuromodulatory methods has increased. I present an overview of basic stimulation methods, their use in the treatment of anorexia nervosa (AN), bulimia nervosa and binge-eating and the results of our study focused on the treatment of AN by transcranial direct current stimulation (tDCS). Methods: It was a randomized, double-blind, sham-controlled trial. Forty-three inpatients with AN were divided to receive either active (n=22) or sham (n=21) tDCS over the left DLPFC (anode F3/cathode Fp2, 2mA for 30 minutes). All patients filled the Eating Disorder Examination Questionnaire (EDE-Q) and Zung depression scale (ZUNG), we measured them the thermal pain threshold, the objective dissatisfaction with their own body by Anamorfic program and evaluated BMI before the first and after the last tDCS. Follow-up was after 2 and 4 weeks. It was evaluated using ANOVA and OPLS model. Results: Compared to sham tDCS, active tDCS improved self-evaluation based on one's body shape (p < 0,05) and significantly decreased the need of excessive control over calorie intake (p < 0,05) in 4-week follow-up (questions 4 and 23 in EDE-Q). Question 21 in EDE-Q was more...
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Neuromodulation-the importance ofpostoperativeepiduralfibrosis
Masopust, Václav ; Pokorný, Jaroslav (advisor) ; Suchomel, Petr (referee) ; Hakl, Marek (referee)
Background Epidural fibrosis (EF) is defined as nonphysiological scar formation, usually at the site of neurosurgical access into the spinal canal, in intimate vicinity to and around the origin of the radicular sheath. From the very onset, EF behaves as a reparative inflammation causing, as a rule, symptoms of characteristic nature and clinical course (pain). Treatment of epidural fibrosis causing failed back surgery syndrome (FBSS) by neuromadulation technique is very expensive. Finding of suitable parameters for the indication of treatment is therefore very important. Aims The study is based on evidence of the importance of epidural fibrosis for the development of chronic pain. Research is also focused on the comparison of the range fibrosis and the effect of stimulation (spinal cord stimulation - SCS). The goal is to find a suitable selection factor for the indication of neuromodulation. Methods I. A double-blind prospective study was conducted to investigate a cohort of 200 patients requiring surgical treatment for intervertebral disc hernia (hernia disci intervertebralis). The patients were randomly and blindly divided into 2 groups, one on peroperatively applied local doses of a mixture containing corticosteroids, the other without such medication. All the requirements of a double-blind...
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Neuromodulation-the importance ofpostoperativeepiduralfibrosis
Masopust, Václav ; Pokorný, Jaroslav (advisor) ; Suchomel, Petr (referee) ; Hakl, Marek (referee)
Background Epidural fibrosis (EF) is defined as nonphysiological scar formation, usually at the site of neurosurgical access into the spinal canal, in intimate vicinity to and around the origin of the radicular sheath. From the very onset, EF behaves as a reparative inflammation causing, as a rule, symptoms of characteristic nature and clinical course (pain). Treatment of epidural fibrosis causing failed back surgery syndrome (FBSS) by neuromadulation technique is very expensive. Finding of suitable parameters for the indication of treatment is therefore very important. Aims The study is based on evidence of the importance of epidural fibrosis for the development of chronic pain. Research is also focused on the comparison of the range fibrosis and the effect of stimulation (spinal cord stimulation - SCS). The goal is to find a suitable selection factor for the indication of neuromodulation. Methods I. A double-blind prospective study was conducted to investigate a cohort of 200 patients requiring surgical treatment for intervertebral disc hernia (hernia disci intervertebralis). The patients were randomly and blindly divided into 2 groups, one on peroperatively applied local doses of a mixture containing corticosteroids, the other without such medication. All the requirements of a double-blind...
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An external pulse generator for neuromodulation
Flídr, Lukáš ; Čech, Petr (referee) ; Chmelař, Milan (advisor)
The main objective of this work is to explain and familiarize with neuromodulation, its use and possibilities of its application in current medicine. It will also focus on the basic configuration and the block concept of an external generator and the time courses of the generator are described. In the first phase the base of neuromodulation is explained, then the main application, the implementation of this technology and the possibility of its application in modern medicine. Further to the work we will find an overview of equipment used for neuromodulation. The other part is focused on a design of an external generator using a MOTOROLA Nitron HC08 series microcontroller, its configuration and finally description of the time courses (impulses) from the device, that are used for neuromodulation.
|
|
|
External pulse generator for neuromodulation
Flídr, Lukáš ; Říčný, Václav (referee) ; Chmelař, Milan (advisor)
This thesis deals with the treatment of chronic pain by using neuromodulation, where a external generator is used in a trial period. In the first section the principle of pain management is described and then the main nature of neuromodulation. The possibilities of chronic pain suppression are described, where we are mainly dealing with neurostimulation (stimulation with electric current). For better understanding, examples of neurostimulation usage are shown, where and in what problems it is used. Because this work deals with an external generator for a trial period (a trial system), the possibilities of testing electric impulses are described, which are then used in a implantable generator IPG. The requirements for such a external generator are also described, which are important for the design of such a device. The design of the device is firstly modeled by a block scheme, where function of the separate blocks is described and afterwards, the entire design of the external generator for neuromodulation is given. The test sample of the external generator is manufactured and tested.
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